Project A6

Project Description

Project A6 addresses the virulence of the emerging pathogen Lichtheimia corymbifera, a ubiquitous, saprobic filamentous soil fungus. The genome of L. corymbifera was sequenced and analysed in depth by A6. Comparative analyses of the virulence potential of 16 L. corymbifera strains using infection models and proteomic profiling identified the hydrophobic binding protein HsbA as a key mediator in the interaction of L. corymbifera with macrophages. A6 aims at elucidating the role of HbsA and other surface proteins for pathogenicity.

Principal Investigator

Dr. Kerstin Voigt
PD Dr. Kerstin Voigt

Institute of Microbiology

Department of Microbiology and Molecular Biology

Friedrich Schiller University Jena

kerstin.voigt@leibniz-hki.de

Publications

Author Year Title Journal Links
Schulze B, Rambach G, Schwartze VU, Voigt K, Schubert K, Speth C, Jacobsen ID 2017 Ketoacidosis alone does not predispose to mucormycosis by Lichtheimia in a murine pulmonary infection model.

Virulence doi: 10.1080/21505594.2017.1360460. [Epub ahead of print]

PubMed