Project B5

Project Description

Project B5 investigates the role of human microbiota for the development of fungal infectious diseases. The main hypothesis is that the observed high rate of Candida albicans infections in patients undergoing chemotherapeutic or antibiotic treatment is highly interconnected with drug-induced imbalances of the intestinal ecosystem. B5 will determine the composition and functionality of bacteria and viruses from human and mouse gut. B5 will examine how microbes influence the colonisation of C. albicans. By high throughput sequencing, metagenome and metatranscriptome data from different time points before and after colonization/infection will be generated. Also, regulatory genes (e.g. ncRNAs) will be identified.

Principal Investigator

Prof. Dr. Manja Marz
Prof. Dr. Manja Marz

Faculty of Mathematics and Computer Science  Bioinformatics/High Throughput Analysis

Friedrich Schiller University Jena

Dr. Gianni Panagiotou
Dr. Gianni Panagiotou

Research Group Systems Biology and Bioinformatics

Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute


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