The role of human microbiota for the development of fungal infectious diseases – Candida albicans as a case study
Project B5 investigates the role of human microbiota for the development of fungal infectious diseases. The main hypothesis is that the observed high rate of Candida albicans infections in patients undergoing chemotherapeutic or antibiotic treatment is highly interconnected with drug-induced imbalances of the intestinal ecosystem. B5 will determine the composition and functionality of bacteria and viruses from human and mouse gut. B5 will examine how microbes influence the colonisation of C. albicans. By high throughput sequencing, metagenome and metatranscriptome data from different time points before and after colonization/infection will be generated. Also, regulatory genes (e.g. ncRNAs) will be identified.
Prof. Dr. Manja Marz
Faculty of Mathematics and Computer Science Bioinformatics/High Throughput Analysis
Friedrich Schiller University Jena
Dr. Gianni Panagiotou
Research Group Systems Biology and Bioinformatics
Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute
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