New paper about Aspergillus fumigatus (A1)
An international research team including Prof. Dr. Axel Brakhage (FungiNet project A1) and Prof. Dr. Christian Hertweck from the Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI) in Jena discovered how the filamentous fungus Aspergillus fumigatus inhibits the immune response of the human host. This can lead to the establishment of life-threatening opportunistic fungal infections. The research was led by Oliver Werz at Friedrich Schiller University in Jena and is published in Cell Chemical Biology.
König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O (2019) Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolase. Cell Chemical Biology 26: 1-11.
Link to PubMed