At the wrong time in the wrong place
How the intestinal fungus Candida albicans shapes our immune system
Cell paper by Projects A1, C1 and Z2
Members of the Clusters of Excellence “Balance of the Microverse” and “Precision Medicine in Chronic Inflammation” as well as members of TRR 124 FungiNet have decoded a mechanism, how specific intestinal microbiomes exacerbate inflammatory diseases at other body sites, such as the lungs.
Original paper:
Bacher P, Hohnstein T, Beerbaum E, Röcker M, Kaufmann S, Brandt C, Röhmel J, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Heine G, Worm M, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Brunke S, Hube B, Blango M, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019) Instruction of human anti-fungal Th17 immunity and immune pathology by cross-reactivity against a single member of the microbiota. Cell 176: 1340-55.