Project B5

The role of human microbiota for the development of fungal infectious diseases – Candida albicans as a case study

Project B5 investigates the role of human microbiota in the development of fungal infectious diseases. The main hypothesis is that the observed high rate of Candida albicans infections in patients undergoing chemotherapeutic or antibiotic treatment is highly interconnected with drug-induced imbalances of the intestinal ecosystem. B5 will determine the composition and functionality of bacteria and viruses from human and mouse gut and will examine how microbes influence the colonization of C. albicans. By high throughput sequencing, metagenome and metatranscriptome data from different time points before and after colonization/infection will be generated.

The new systemic view of the intertwined nature of C. albicans infections, drug administration and gut microbiota will be generated on the basis of the following aims:

  • Analyzing the diversity and functionality of the gut microbiome and the contribution to C. albicans colonization and dissemination
  • Characterization of RNAs from extracellular microvesicles
  • Further developing the data-warehouse FungiNetDB for the analysis and storage of 16S rRNA, metagenomic, metatranscriptomic and virome data.
Principal Investigators
Prof. Dr. Manja Marz
Prof. Dr. Manja Marz

Faculty of Mathematics and Computer Science  Bioinformatics/High Throughput Analysis

Friedrich Schiller University Jena

Author Year Title Journal Links
Patumcharoenpol P, Nakphaichit M, Panagiotou G, Senavonge A, Suratannon N, Vongsangnak W 2021 MetGEMs Toolbox: Metagenome-scale models as integrative toolbox for uncovering metabolic functions and routes of human gut microbiome. PLoS Computational Biology 17: e1008487 PubMed
Kang K, Imamovic L, Misiakou MA, Bornakke Sørensen M, Heshiki Y, Ni Y, Zheng T, Li J, Ellabaan MMH, Colomer-Lluch M, Rode AA, Bytzer P, Panagiotou G, Sommer MOA 2021 Expansion and persistence of antibiotic-specific resistance genes following antibiotic treatment. Gut Microbes 13: 1-19 PubMed
Haange SB, Jehmlich N, Krügel U, Hintschich C, Wehrmann D, Hankir M, Seyfried F, Froment J, Hübschmann T, Müller S, Wissenbach DK, Kang K, Buettner C, Panagiotou G, Noll M, Rolle-Kampczyk U, Fenske W, von Bergen M 2020 Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss. Microbiome 8: 13 PubMed
Çakır T, Panagiotou G, Uddin R, Durmuş S 2020 Novel approaches for Systems Biology of metabolism-oriented pathogen-human interactions: A mini-review. Front Cell Infect Microbiol 10: 52 (Review) Frontiers
Heshiki Y, Vazquez-Uribe R, Li J, Ni Y, Quainoo S, Imamovic L, Li J, Sørensen M, Chow BKC, Weiss GJ, Xu A, Sommer MOA, Panagiotou G 2020 Predictable modulation of cancer treatment outcomes by the gut microbiota. Microbiome 8: 28 PubMed
Blango MG, Pschibul A, Rivieccio F, Krüger T, Muhammad R, Jia L, Zheng T, Goldmann M, Voltersen V, Li Jun, Panagiotou G, Kniemeyer O, Brakhage AA 2020 Dynamic surface proteomes of allergenic fungal conidia. J Proteome Res 19: 2092-104 PubMed
Dissanayake TK, Schäuble S, Mirhakkak M, Wu WL, Ng ACK, Yip CCY, López AG, Yeung ML, Chan KH, Yuen KY, Panagiotou G, To KKW 2020 Comparative transcriptomic analysis of Rhinovirus and Influenza virus infection. Front Microbiol 11: 1580 PubMed
Seelbinder B, Chen J, Brunke S, Uribe RV, Meyer AC, de Oliveira Lino FS, Chan KF, Loos D, Imamovic L, Tsang CC, Lam RPK, Sridhar S, Kang K, Hube B, Woo PCY, Sommer MOA, Panagiotou G 2020 Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome 8: 133 Microbiome
Seelbinder B, Wallstabe J, Marischen L, Weiss E, Wurster S, Page L, Löffler C, Bussemer L, Schmitt A, Wolf T, Becker J, Kalinke U, Vogel J, Panagiotou G, Einsele H, Westermann A, Schäuble S, Loeffler J 2020 RNA-seq reveals synergy in a human virus-fungus co-infection model. Cell Rep 33: 108389 PubMed
Barber A, Riedel J, Sae-Ong T, Kang K, Brabetz W, Panagiotou G, Deising H, Kurzai O 2020 Effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure. mBio 11: e02213-20 PubMed
Mirhakkak MH, Schäuble S, Klassert TE, Brunke S, Brandt P, Loos D, Uribe RV, Senne de Oliveira Lino F, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss GJ, Sommer MOA, Panagiotou G 2020 Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J 15: 1257-70 PubMed
Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A 2019 Gut microbiome fermentation determines the efficacy of exercise for diabetes prevention. Cell Metab 31: 77-91 PubMed
Kang K, Bergdahl B, Machado D, Dato L, Han TL, Li J, Villas-Boas S, Herrgård MJ, Förster J, Panagiotou G 2019 Linking genetic, metabolic and phenotypic diversity among S. cerevisiae strains using multi-omics associations. Gigascience 8: giz015 PubMed
Li J, Rettedal EA, van der Helm E, Ellabaan M, Panagiotou G, Sommer MOA 2019 Antibiotic treatment drives the diversification of the human gut resistome Genomics Proteomics Bioinformatics 17: 39-51 PubMed
Zheng T, Li J, Ni Y, Kang K, Misiakou MA, Imamovic L, Chow BKC, Rode AA, Bytzer P, Sommer M, Panagiotou P 2019 Mining, analyzing and integrating viral signals from metagenomic data. Microbiome 7: 42 PubMed