Project C7

Ionic regulation of Th17-mediated immune responses to Candida infection

Project C7 will expand the immunological expertise in research area C with a focus on T-cell immunology. The PIs of this project have previously shown that ionic signals, such as Na+ and Ca2+ gradients, are critical for the differentiation and function of murine and human Th17 cells. C7N will now investigate how ionic signals shape anti-fungal immune responses in local and systemic C. albicans infection models in mice and humans. C7 focusses in particular on Th17-cell-mediated immune responses and will identify transcriptional and metabolic factors downstream of ionic signaling as potential molecular target to augment anti-fungal immune responses in vivo.

Principal Investigators
Prof. Dr. Christina Zielinski
Prof. Dr. Christina Zielinski

Department of Infection Immunology

Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute

Dr. Martin Vaeth
Dr. Martin Vaeth

Institute of Systems Immunology

Julius Maximilians University Würzburg

Author Year Title Journal Links
Yin H, Karayel O, Chao YY, Seeholzer T, Hamp I, Plettenburg O, Gehring T, Zielinski C, Mann M, Krappmann D. 2022 A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells. Cell Mol Life Sci. 79(2): 112 PubMed
de Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Mädler SC, Kloeppel M, Verbeek M, Zielinski CE 2022 Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. Sci Immunol. 7(67): eabe2634 PubMed
Wu H, Brand B, Eckstein M, Hochrein SM, Shumanska M, Dudek J, Nickel A, Maack C, Bogeski I, Vaeth M 2021 Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo. Front. Pharmacol. 12: 734078 PubMed
Chu CF, Sabath F, Fibi-Smetana S, Sun S, Öllinger R, Noessner E, Chao YY, Rinke L, Winheim E, Rad R, Krug AB, Taher L, Zielinski CE 2021 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities. Frontiers in Immunology 12: 601080 PubMed
Zielinski CE 2021 Regulation of T Cell Responses by Ionic Salt Signals. Cells. 10(9): 2365 PubMed
Arunkumar M, Zielinski CE 2021 T-Cell Receptor Repertoire Analysis with Computational Tools-An Immunologist’s Perspective. Cells. 10(12): 3582. PubMed
Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE 2020 Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. J Clin Invest 130: 4587-600 PubMed