Project C7
Ionic regulation of Th17-mediated immune responses to Candida infection
Project C7 will expand the immunological expertise in research area C with a focus on T-cell immunology. The PIs of this project have previously shown that ionic signals, such as Na+ and Ca2+ gradients, are critical for the differentiation and function of murine and human Th17 cells. C7N will now investigate how ionic signals shape anti-fungal immune responses in local and systemic C. albicans infection models in mice and humans. C7 focusses in particular on Th17-cell-mediated immune responses and will identify transcriptional and metabolic factors downstream of ionic signaling as potential molecular target to augment anti-fungal immune responses in vivo.
Principal Investigators
Publications
| Author | Year | Title | Journal | Links |
|---|---|---|---|---|
| Soll D, Chu CF, Sun S, Lutz V, Arunkumar M, Gachechiladze M, Schäuble S, Alissa-Alkhalaf M, Nguyen T, Khalil MA, Garcia-Ribelles I, Mueller M, Buder K, Michalke B, Panagiotou G, Ziegler-Martin K, Benz P, Schatzlmaier P, Hiller K, Stockinger H, Luu M, Schober K, Moosmann C, Schamel WW, Huber M, Zielinski CE | 2024 | Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity. | Nat Immunol. | PubMed |
| Musiol S, Harris CP, Gschwendtner S, Burrell A, Amar Y, Schnautz B, Renisch D, Braun SC, Haak S, Schloter M, Schmidt-Weber CB, Zielinski CE, Alessandrini F | 2024 | The impact of high-salt diet on asthma in humans and mice: Effect on specific T-cell signatures and microbiome. | Allergy | PubMed |
| May L, Chu CF, Zielinski CE | 2024 | Single-Cell RNA Sequencing Reveals HIF1A as a Severity-Sensitive Immunological Scar in Circulating Monocytes of Convalescent Comorbidity-Free COVID-19 Patients. | Cells. 13(4):300 | PubMed |
| Batliner M, Schumacher F, Wigger D, Vivas W, Prell A, Fohmann I, Köhler T, Schempp R, Riedel A, Vaeth M, Fekete A, Kleuser B, Kurzai O, Nieuwenhuizen NE | 2024 | The Candida albicans quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells. | mBio 2:e0073224 | PubMed |
| Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE. | 2023 | Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation. | Nat Immunol. 24(2):295-308 | PubMed |
| Meiser P, Knolle MA, Hirschberger A, de Almeida GP, Bayerl F, Lacher S, Pedde AM, Flommersfeld S, Hönninger J, Stark L, Stögbauer F, Anton M, Wirth M, Wohlleber D, Steiger K, Buchholz VR, Wollenberg B, Zielinski CE, Braren R, Rueckert D, Knolle PA, Kaissis G, Böttcher JP | 2023 | A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. | Cancer Cell. 11: S1535-6108 | PubMed |
| Wu H, Zhao X, Hochrein SM, Eckstein M, Gubert GF, Knöpper K, Mansilla AM, Öner A, Doucet-Ladevèze R, Schmitz W, Ghesquière B, Theurich S, Dudek J, Gasteiger G, Zernecke A, Kobold S, Kastenmüller W, Vaeth M | 2023 | Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming | Nat Commun. 14(1):6858 | PubMed |
| Zielinski CE | 2023 | T helper cell subsets: diversification of the field. | Eur J Immunol. 53(12) | PubMed |
| Yin H, Karayel O, Chao YY, Seeholzer T, Hamp I, Plettenburg O, Gehring T, Zielinski C, Mann M, Krappmann D. | 2022 | A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells. | Cell Mol Life Sci. 79(2): 112 | PubMed |
| de Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Mädler SC, Kloeppel M, Verbeek M, Zielinski CE | 2022 | Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. | Sci Immunol. 7(67): eabe2634 | PubMed |
| Hochrein SM, Wu H, Eckstein M, Arrigoni L, Herman JS, Schumacher F, Gerecke C, Rosenfeldt M, Grün D, Kleuser B, Gasteiger G, Kastenmüller W, Ghesquière B, Van den Bossche J, Abel ED, Vaeth M. | 2022 | The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. | Cell Metab 34(4):516-532 | PubMed |
| Wu H, Brand B, Eckstein M, Hochrein SM, Shumanska M, Dudek J, Nickel A, Maack C, Bogeski I, Vaeth M | 2021 | Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo. | Front. Pharmacol. 12: 734078 | PubMed |
| Chu CF, Sabath F, Fibi-Smetana S, Sun S, Öllinger R, Noessner E, Chao YY, Rinke L, Winheim E, Rad R, Krug AB, Taher L, Zielinski CE | 2021 | Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities. | Frontiers in Immunology 12: 601080 | PubMed |
| Zielinski CE | 2021 | Regulation of T Cell Responses by Ionic Salt Signals. | Cells. 10(9): 2365 | PubMed |
| Arunkumar M, Zielinski CE | 2021 | T-Cell Receptor Repertoire Analysis with Computational Tools-An Immunologist’s Perspective. | Cells. 10(12): 3582. | PubMed |
| Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE | 2020 | Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. | J Clin Invest 130: 4587-600 | PubMed |