Surface proteins of Lichtheimia corymbifera as virulence determinants
Project A6 addresses the virulence of the emerging pathogen Lichtheimia corymbifera, a ubiquitous, saprobic filamentous soil fungus. The genome of L. corymbifera was sequenced and analysed in depth by A6. Comparative analyses of the virulence potential of 16 L. corymbifera strains using infection models and proteomic profiling identified the hydrophobic binding protein HsbA as a key mediator in the interaction of L. corymbifera with macrophages. A6 aims at elucidating the role of HbsA and other surface proteins for pathogenicity.
PD Dr. Kerstin Voigt
Institute of Microbiology
Department of Microbiology and Molecular Biology
Friedrich Schiller University Jena
Schulze B, Rambach G, Schwartze VU, Voigt K, Schubert K, Speth C, Jacobsen ID
Ketoacidosis alone does not predispose to mucormycosis by Lichtheimia in a murine pulmonary infection model.
Virulence 8: 1657-67