Project C2

Regulation of Candida albicans virulence traits by protein kinases

The reversible phosphorylation of effector proteins is a common mechanism to trigger cellular reactions in response to extracellular and intracellular signals in all organisms. The aim of project C2 is a comprehensive functional analysis of all protein kinases of the human-pathogenic yeast C. albicans to gain insight into their role and importance for the adaptation of this fungal pathogen to different environmental conditions during colonization and infection of its host.

Principal Investigators
Prof. Dr. Joachim Morschhäuser
Prof. Dr. Joachim Morschhäuser

Institute for Molecular Infection Biology and Research Center for Infectious Diseases (ZINF)  

Julius Maximilians University Würzburg

Dr. Slavena Vylkova
Dr. Slavena Vylkova

Center for Innovation Competence (ZIK) Septomics  
Research group Host Fungal Interfaces 

Friedrich Schiller University Jena

Author Year Title Journal Links
Böttcher B, Hoffmann B, Garbe E, Weise T, Cseresnyés Z, Brandt P, Dietrich S, Driesch D, Figge MT, Vylkova S 2020 The transcription factor Stp2 is important for Candida albicans biofilm establishment and sustainability. Front Microbiol 11: 794 PubMed
Ruben S, Garbe E, Mogavero S, Albrecht-Eckardt D, Hellwig D, Häder A, Krüger T, Gerth K, Jacobsen ID, Elshafee O, Brunke S, Hünniger K, Kniemeyer O, Brakhage AA, Morschhäuser J, Hube B, Vylkova S, Kurzai O, Martin R 2020 Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. mBio 11: e00206-20 PubMed
Gerwien F, Dunker C, Brandt P, Garbe E, Jacobsen ID, Vylkova S 2020 Clinical Candida albicans vaginal isolates and a laboratory strain show divergent behaviors during macrophage interactions. mSphere 5: e00393-20 PubMed
Brandt P, Garbe E, Vylkova S 2020 Catch the wave: Metabolomic analyses in human pathogenic fungi. PLoS Pathog 16: e1008757 (Review) PubMed
Mottola A, Schwanfelder S, Morschhäuser J 2020 Generation of viable Candida albicans mutants lacking the “essential” protein kinase Snf1 by inducible gene deletion. mSphere 5: e00805-20 PubMed
Mirhakkak MH, Schäuble S, Klassert TE, Brunke S, Brandt P, Loos D, Uribe RV, Senne de Oliveira Lino F, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss GJ, Sommer MOA, Panagiotou G 2020 Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J [Epub ahead of print] PubMed
von Müller C, Bulman F, Wagner L, Rosenberger D, Marolda A, Kurzai O, Eißmann P, Jacobsen ID, Perner B, Hemmerich P, Vylkova S 2020 Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants. Sci Rep 10: 21818 PubMed
Popp C, Ramírez-Zavala B, Schwanfelder S, Krüger I, Morschhäuser J 2019 Evolution of fluconazole-resistant Candida albicans strains by drug-induced mating competence and parasexual recombination. mBio 10: e02740-18 PubMed
Mottola A, Morschhäuser J 2019 An intragenic recombination event generates a Snf4-independent form of the essential protein kinase Snf1 in Candida albicans. mSphere 4: e00352-19 Pubmed
Allert S*, Förster TM*, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B; *authors contributed equally 2018 Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9: e00915-18 PubMed
Ramírez-Zavala B, Manz H, Englert F, Rogers PD, Morschhäuser J 2018 A hyperactive form of the zinc cluster transcription factor Stb5 causes YOR1 overexpression and beauvericin resistance in Candida albicans. Antimicrob Agents Chemother 62: e01655-18 PubMed
Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J 2017 The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans. Mol Microbiol 104: 989-1007 PubMed
Hampe IAI, Friedman J, Edgerton M, Morschhäuser J 2017 An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses. PLoS Pathog 13: e1006655 PubMed
Morschhäuser J 2016 The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen. J Microbiol 54: 192-201 PubMed