Project C2

Regulation of Candida albicans virulence traits by protein kinases

The reversible phosphorylation of effector proteins is a common mechanism to trigger cellular reactions in response to extracellular and intracellular signals in all organisms. The aim of project C2 is a comprehensive functional analysis of all protein kinases of the human-pathogenic yeast C. albicans to gain insight into their role and importance for the adaptation of this fungal pathogen to different environmental conditions during colonization and infection of its host.

Principal Investigators
Prof. Dr. Joachim Morschhäuser
Prof. Dr. Joachim Morschhäuser

Institute for Molecular Infection Biology and Research Center for Infectious Diseases (ZINF)  

Julius Maximilians University Würzburg

Dr. Slavena Vylkova
Dr. Slavena Vylkova

Center for Innovation Competence (ZIK) Septomics  
Research group Host Fungal Interfaces 

Friedrich Schiller University Jena

Author Year Title Journal Links
Popp C, Ramírez-Zavala B, Schwanfelder S, Krüger I, Morschhäuser J 2019 Evolution of fluconazole-resistant Candida albicans strains by drug-induced mating competence and parasexual recombination. mBio 10: e02740-18 PubMed
Mottola A, Morschhäuser J 2019 An intragenic recombination event generates a Snf4-independent form of the essential protein kinase Snf1 in Candida albicans. mSphere 4: e00352-19 Pubmed
Allert S*, Förster TM*, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B; *authors contributed equally 2018 Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9: e00915-18 PubMed
Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J 2017 The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans. Mol Microbiol 104: 989-1007 PubMed
Hampe IAI, Friedman J, Edgerton M, Morschhäuser J 2017 An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses. PLoS Pathog 13: e1006655 PubMed
Morschhäuser J 2016 The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen. J Microbiol 54: 192-201 PubMed