Project A8

Gene-engineered CAR T-cells and macrophages to treat Aspergillus fumigatus infection

T-cells engineered to express a chimeric antigen receptor (CAR) showed tremendous success in treating B cell malignancies. Project A8 aims to equip innate and adaptive immune cells with a CAR targeting A. fumigatus and define the optimal cell product for adoptive immunotherapy of invasive aspergillosis.

We will focus on the genetic engineering of T-cells and macrophages to direct their specificity to A. fumigatus. We will pursue three complementary and synergistic strategies to augment and fine tune the activity of A. fumigatus-specific CAR (Af-CAR) T-cells. One strategy is to use a co-receptor to enhance reactivity and selectivity of Af-CAR T-cells. Another strategy is to express an inducible IL-12 reporter gene in Af-CAR T-cells to augment the recruitment and activation of innate immune cells. In parallel, the anti-fungal activity of macrophages that are equipped with the Af-CAR will be evaluated alone and in combination with Af-CAR T-cells.

Summary of research to Gene-engineered CAR T-cells and macrophages reactive to A. fumigatus Some illustrations were obtained and modified from Servier Medical Art by Servier, licensed under Creative Commons Attribution 3.0 Unported License.
Summary of research to Gene-engineered CAR T-cells and macrophages reactive to A. fumigatus. Some illustrations were obtained and modified from Servier Medical Art by Servier, licensed under Creative Commons Attribution 3.0 Unported License.
Principal Investigator
Prof. Dr. Michael Hudecek
Prof. Dr. Michael Hudecek

Faculty of Medicine, Department of Internal Medicine II and Research Center for Infectious Diseases (ZINF)  

Julius Maximilians University Würzburg

hudeceklab@ukw.de

Prof. Dr. Hermann Einsele
Prof. Dr. Hermann Einsele

Faculty of Medicine, Department of Internal Medicine II and Research Center for Infectious Diseases (ZINF)  

Julius Maximilians University Würzburg

einsele_h@klinik.uni-wuerzburg.de

Publications

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